Search results for "cationic nanoparticles"

Delivery of shRNA plasmid DNA by cationic solid lipid nanoparticles for gene silencing in human hepatocarcinoma cells

2015

Cationic Solid Lipid Nanoparticles (SLN) for shNupr1 plasmid delivery in the treatment of hepatocellular carcinoma (HCC)

2016

Cationic solid lipid nanoparticles complexed with genetic material for liver tumor treatment

2015

Concept Gene therapy is a growing field of medicine with great potential for the treatment of several diseases and it is based on the delivery of nucleic acids (DNA, RNA, etc.,) to specific cells. To achieve their therapeutic effects, the nucleic acids need to cross several biological barriers and be protected from the degradation by nucleases, present in biological fluids and intracellular compartments, to successfully gain access to their intracellular targets. To overcome these hurdles, it is necessary to deliver the genetic material with biocompatible carriers able to facilitate its translocation across the cell membranes and protect it from being degraded while circulating in the blood…